Research paper on OSTEOPETROSIS Example | Topics and Well Written Essays - 500 words

On OSTEOPETROSIS - enquiry Paper ExampleMortality associated with infantile osteopetrosis is high. Those with adult osteopetrosis have longterm survival chances. In this research essay, the pathophysiology, clinical presentation, investigations, treatment and prevention will be discussed. Purpose The main purpose of the musical composition is to present an overview of osteopetrosis. Pathophysiology The main defect in osteopetrosis is in osteoclast which belongs to monocyte-macrophage lineage and genetic defects leads to abnormal osteoclasts (Tolar et al, 2004). Osteoclasts atomic number 18 very important in the modelling and altering of the wind of the bone and defective osteoclasts fail to model and remodel the bone appropriately, resulting in abnormal encroachment and deposition of bone tissue (Teitelbaum, 2000). The abnormal bone tissue is susceptible to fractures and can encroach into the bone marrow leading to bone marrow failure. it can besides encroach around the nerves c ausing nerve entrapment syndrome. When blood vessels are affected, ischemia, especially of the bones standardised mandible can occur. Eventually, the patient develops multiple fractures, anemia, bleeding disorders and sepsis (Bhargava, and Griffing, 2009). Clinical presentation The clinical presentation depends on the type of osteopetrosis.